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These studies account for the level of nicotine in the participant's system by allowing frequent smoke breaks so as to avoid inducing a state of withdrawal ( Interestingly, this effect is specific to those with schizophrenia, as no such finding was observed in patients with major depression, bipolar disorder or non-psychiatric controls ( Other studies employed cognitive testing in both satiated and abstinent states and demonstrated that smokers with SZ show improvements in various cognitive domains (1

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We found that EI (5 M or higher concentration) played a similar role as AZI to inhibit the secretion of IL-6 (Fig